Benchmark Technology for Cancer Treatment- NANOTECHNOLOGY
Written by admin on Sep 5th, 2009 | Filed under: Cancer
nitesh s chauhan asked:
Search for newer technology has always fascinated researchers. Nano technology is a multidisciplinary field, which recently has emerged as one of the most propitious field in cancer treatment. Nano technology is definitely a medical boon for diagnosis, treatment and prevention of cancer disease. It supports and expands the scientific advances in genomic and proteomics and builds on our understanding of the molecular underpinnings of cancer and its treatment. The various nanotechnological approaches in cancer treatment have been encompassed in the current article. One of them includes localized delivery of heat and the localized imaging of biological materials through nanoparticles. The delivery may be in vitro or in vivo and is useful for the localized treatment of cancer and disorders involving over proliferation of tissue. Other approach relates to a novel process of manufacture of nanoparticles of substantially water insoluble materials from emulsions. These emulsions have the ability to form a single liquid phase upon dilution of the external phase, instantly producing dispersible solid nanoparticles. The formed nanoparticles can be used in a wide range of therapeutic treatments of cancer. Additional approach comprises of solid tumors having an acidic extra cellular environment and an altered pH gradient across their cell compartments. Nanoparticles responsive to the pH gradients are promising for cancer drug delivery. Such pH-responsive nanoparticles consist of a corona and a core, one or both of which respond to the external pH to change their soluble/insoluble or charge states, thereby they have therapeutic advantages over the conventional pH-insensitive counterparts. An alternative advancement discloses a method/system utilizing interaction of electromagnetic pulses or ultrasonic radiation with nano- and micro particles for enhancement of drug delivery in solid tumors. These particles can be attached to antibodies directed against antigens in tumor vasculature and selectively delivered to tumor blood vessel wall. A widespread understanding of these new technologies can provide essential breakthroughs in the fight against cancer.
Tiny man-made nanoparticles have been used to successfully smuggle a powerful cancer drug into tumor cells leaving healthy cells unharmed. When tested in mice, the Nan structure-based therapy was 10 times as effective at delaying tumor growth and far less toxic than the drug given alone. Researchers believe the therapy could transform many cancers from killer into chronic, treatable diseases.4,5 The major goals in designing nanoparticles as a delivery system are to control particle size, surface properties and release of pharmacologically active agents in order to achieve the site-specific action of the drug at the therapeutically optimal rate and dose regimen. Though liposome have been used as potential carriers with unique advantages including protecting drugs from degradation, targeting to site of action and reduction toxicity or side effects, their applications are limited due to inherent problems such as low encapsulation efficiency, rapid leakage of water-soluble drug in the presence of blood components and poor storage stability. On the other hand, polymeric nanoparticles offer some specific advantages over liposome. For instance, they help to increase the stability of drugs/proteins and possess useful controlled release properties. The purpose of the chemotherapy and radiation is to kill the tumor cells as these cells are more susceptible to the actions of these drugs and methods because of their growth at a much faster rate than healthy cells, at least in adults. Research efforts to improve chemotherapy over the past 25 years have led to an improvement in patient survival but there is still a need for improvement.6, 7 Current research areas include development of carriers to allow alternative dosing routes, new therapeutic targets such as blood vessels fueling tumor growth and targeted therapeutics that are more specific in their activity. Several nano biotechnologies mostly based on nanoparticles, have been used to facilitate drug delivery in cancer. The magic of nanoparticles mesmerizes everyone because of their multifunctional character and they have given us hope for the recovery from this disease. Although we are practicing better drug delivery paths into the body, we ultimately seek more accurate protocols to eradicate cancer from our society. This review will primarily address new methods for delivering drugs, both old and new, with a focus on nano particle formulations and ones that specifically target tumors.
Search for newer technology has always fascinated researchers. Nano technology is a multidisciplinary field, which recently has emerged as one of the most propitious field in cancer treatment. Nano technology is definitely a medical boon for diagnosis, treatment and prevention of cancer disease. It supports and expands the scientific advances in genomic and proteomics and builds on our understanding of the molecular underpinnings of cancer and its treatment. The various nanotechnological approaches in cancer treatment have been encompassed in the current article. One of them includes localized delivery of heat and the localized imaging of biological materials through nanoparticles. The delivery may be in vitro or in vivo and is useful for the localized treatment of cancer and disorders involving over proliferation of tissue. Other approach relates to a novel process of manufacture of nanoparticles of substantially water insoluble materials from emulsions. These emulsions have the ability to form a single liquid phase upon dilution of the external phase, instantly producing dispersible solid nanoparticles. The formed nanoparticles can be used in a wide range of therapeutic treatments of cancer. Additional approach comprises of solid tumors having an acidic extra cellular environment and an altered pH gradient across their cell compartments. Nanoparticles responsive to the pH gradients are promising for cancer drug delivery. Such pH-responsive nanoparticles consist of a corona and a core, one or both of which respond to the external pH to change their soluble/insoluble or charge states, thereby they have therapeutic advantages over the conventional pH-insensitive counterparts. An alternative advancement discloses a method/system utilizing interaction of electromagnetic pulses or ultrasonic radiation with nano- and micro particles for enhancement of drug delivery in solid tumors. These particles can be attached to antibodies directed against antigens in tumor vasculature and selectively delivered to tumor blood vessel wall. A widespread understanding of these new technologies can provide essential breakthroughs in the fight against cancer.
Tiny man-made nanoparticles have been used to successfully smuggle a powerful cancer drug into tumor cells leaving healthy cells unharmed. When tested in mice, the Nan structure-based therapy was 10 times as effective at delaying tumor growth and far less toxic than the drug given alone. Researchers believe the therapy could transform many cancers from killer into chronic, treatable diseases.4,5 The major goals in designing nanoparticles as a delivery system are to control particle size, surface properties and release of pharmacologically active agents in order to achieve the site-specific action of the drug at the therapeutically optimal rate and dose regimen. Though liposome have been used as potential carriers with unique advantages including protecting drugs from degradation, targeting to site of action and reduction toxicity or side effects, their applications are limited due to inherent problems such as low encapsulation efficiency, rapid leakage of water-soluble drug in the presence of blood components and poor storage stability. On the other hand, polymeric nanoparticles offer some specific advantages over liposome. For instance, they help to increase the stability of drugs/proteins and possess useful controlled release properties. The purpose of the chemotherapy and radiation is to kill the tumor cells as these cells are more susceptible to the actions of these drugs and methods because of their growth at a much faster rate than healthy cells, at least in adults. Research efforts to improve chemotherapy over the past 25 years have led to an improvement in patient survival but there is still a need for improvement.6, 7 Current research areas include development of carriers to allow alternative dosing routes, new therapeutic targets such as blood vessels fueling tumor growth and targeted therapeutics that are more specific in their activity. Several nano biotechnologies mostly based on nanoparticles, have been used to facilitate drug delivery in cancer. The magic of nanoparticles mesmerizes everyone because of their multifunctional character and they have given us hope for the recovery from this disease. Although we are practicing better drug delivery paths into the body, we ultimately seek more accurate protocols to eradicate cancer from our society. This review will primarily address new methods for delivering drugs, both old and new, with a focus on nano particle formulations and ones that specifically target tumors.
